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Investigation of the effects of DNA repair gene polymorphisms on the risk of colorectal cancer.

Abstract:

Despite their prime candidate status, polymorphisms near genes involved in DNA repair or in other functions related to genome stability have been conspicuously under-represented in the significant associations reported from genome-wide association studies (GWAS) of cancer susceptibility. In this study, we assessed a set of single-nucleotide polymorphisms (SNPs) near 157 DNA repair genes in three colorectal cancer (CRC) GWAS. Although no individual SNP showed evidence of association, the set o...

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Publisher copy:
10.1093/mutage/ger070

Authors


Tomlinson, IP More by this author
Houlston, RS More by this author
Montgomery, GW More by this author
Sieber, OM More by this author
Dunlop, MG More by this author
Journal:
Mutagenesis
Volume:
27
Issue:
2
Pages:
219-223
Publication date:
2012-03-05
DOI:
EISSN:
1464-3804
ISSN:
0267-8357
URN:
uuid:f322a97e-19ea-4eca-bd6b-e917172ab6fa
Source identifiers:
245901
Local pid:
pubs:245901

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