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Kinetics of insulin-like growth factor II (IGF-II) interaction with domain 11 of the human IGF-II/mannose 6-phosphate receptor: function of CD and AB loop solvent-exposed residues.

Abstract:

Ligands of the IGF-II/mannose 6-phosphate receptor (IGF2R) include IGF-II and mannose 6-phosphate modified proteins. Disruption of the negative regulatory effects of IGF2R on IGF-II-induced growth can lead to embryonic lethality and cancer promotion. Of the 15 IGF2R extracellular domains, domains 1-3 and 11 are known to have a conserved beta-barrel structure similar to that of avidin and the cation-dependent mannose 6-phosphate receptor, yet only domain 11 binds IGF-II with high specificity a...

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Publication status:
Published

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Publisher copy:
10.1016/j.jmb.2006.03.046

Authors


Zaccheo, OJ More by this author
Prince, SN More by this author
Miller, DM More by this author
Williams, C More by this author
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Journal:
Journal of molecular biology
Volume:
359
Issue:
2
Pages:
403-421
Publication date:
2006-06-05
DOI:
EISSN:
1089-8638
ISSN:
0022-2836
URN:
uuid:f320269a-9e88-4086-8faa-8f4a7a05df58
Source identifiers:
12008
Local pid:
pubs:12008

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