Preimplantation genetic diagnosis of single-gene disorders: experience with more than 200 cycles conducted by a reference laboratory in the United States.

Journal article

OBJECTIVE: To evaluate trends and outcomes from preimplantation genetic diagnosis (PGD) cycles. DESIGN: Retrospective data review. SETTING: A reference laboratory specializing in the provision of PGD services. PATIENT(S): One hundred sixty-two patients at risk of transmitting a serious monogenic disorder to their children. INTERVENTION(S): In vitro fertilization and PGD. MAIN OUTCOME MEASURE(S): Results of PGD cycles. RESULT(S): Two hundred twenty-four PGD cycles were referred by 59 differen...

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Authors: Gutiérrez-Mateo, C; Sánchez-García, J; Fischer, J; Tormasi, S; Cohen, J

• Publication status: Published
• Journal: Fertility and sterility
• Volume: 92
• Issue: 5
• Pages: 1544-1556
• Publication date: 2009-11-01
• DOI: 10.1016/j.fertnstert.2008.08.111
• EISSN: 1556-5653
• ISSN: 0015-0282
• Language: English
• Keywords: Middle Aged; Genetic Diseases, Inborn; Blastocyst; Adult; United States; Retrospective Studies; Fertilization in Vitro; Male; Preimplantation Diagnosis; Pregnancy; Young Adult; Clinical Laboratory Techniques; Time Factors; Female; False Positive Reactions; Aneuploidy; Humans