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Longstanding complex regional pain syndrome is associated with activating autoantibodies against alpha-1a adrenoceptors.

Abstract:

Complex regional pain syndrome (CRPS) is a limb-confined posttraumatic pain syndrome with sympathetic features. The cause is unknown, but the results of a randomized crossover trial on low-dose intravenous immunoglobulins (IVIG) treatment point to a possible autoimmune mechanism. We tested purified serum immunoglobulin G (IgG) from patients with longstanding CRPS for evidence of antibodies interacting with autonomic receptors on adult primary cardiomyocytes, comparing with control IgG from he...

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Publication status:
Published

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Publisher copy:
10.1016/j.pain.2014.09.022

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Journal:
Pain
Volume:
155
Issue:
11
Pages:
2408-2417
Publication date:
2014-11-05
DOI:
EISSN:
1872-6623
ISSN:
0304-3959
URN:
uuid:f30e4377-f0fc-44e5-b095-40c2e2c8fb58
Source identifiers:
485206
Local pid:
pubs:485206

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