Journal article icon

Journal article

Formation of the definitive endoderm in mouse is a Smad2-dependent process.

Abstract:

TGFbeta growth factors specify cell fate and establish the body plan during early vertebrate development. Diverse cellular responses are elicited via interactions with specific cell surface receptor kinases that in turn activate Smad effector proteins. Smad2-dependent signals arising in the extraembryonic tissues of early mouse embryos serve to restrict the site of primitive streak formation and establish anteroposterior identity in the epiblast. Here we have generated chimeric embryos using ...

Expand abstract
Publication status:
Published

Actions


Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
Journal:
Development (Cambridge, England)
Volume:
127
Issue:
14
Pages:
3079-3090
Publication date:
2000-07-05
EISSN:
1477-9129
ISSN:
0950-1991
URN:
uuid:f30d7856-3e1e-40f6-add5-6aefef85081c
Source identifiers:
12783
Local pid:
pubs:12783

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP