Estimation and implications of the genetic architecture of fasting and non-fasting blood glucose

Journal article

= 11%; standard error: 1%). The genetic correlation between different fasting times is > 0.77, suggesting that the genetic control of glucose is largely constant across fasting durations. Accounting for heritability differences between fasting times leads to a ~16% improvement in the discovery of genetic variants associated with glucose. Newly detected variants improve the prediction of fasting glucose and type 2 diabetes in independent samples. Finally, we meta-analysed summary statistics from genome-wide association studies of random and fasting glucose (N = 518,615) and identified 156 independent SNPs explaining 3% of fasting glucose variance. Altogether, our study demonstrates the utility of random glucose measures to improve the discovery of genetic variants associated with glucose homeostasis, even in fasting conditions.

Authors: Qiao, Z; Sidorenko, J; Revez, JA; Xue, A; Lu, X

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Nature Research
• Journal: Nature Communications
• Volume: 14
• Issue: 1
• Pages: 451-451
• Article number: 451
• Publication date: 2023-01-27
• DOI: 10.1038/s41467-023-36013-1
• EISSN: 2041-1723
• ISSN: 2041-1723
• Language: English
• Keywords: Biology; Economics; Phenotype; Genetic architecture; Internal medicine; Diabetes mellitus; Gene; Geography; Medicine; Estimation; Insulin resistance; Endocrinology; Fasting glucose; Architecture; Genetics