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Glucose-6-phosphate dehydrogenase mutations in malaria endemic area of Thailand by multiplexed high-resolution melting curve analysis

Abstract:
Background Glucose-6-phosphate dehydrogenase (G6PD) deficiency, the most common enzymopathy in humans, is prevalent in tropical and subtropical areas where malaria is endemic. Anti-malarial drugs, such as primaquine and tafenoquine, can cause haemolysis in G6PD-deficient individuals. Hence, G6PD testing is recommended before radical treatment against vivax malaria. Phenotypic assays have been widely used for screening G6PD deficiency, but in heterozygous females, the random l... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

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Role:
Author
ORCID:
0000-0003-0640-6215
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Name:
Thailand Science Research and Innovation
Publisher:
BioMed Central
Journal:
Malaria Journal More from this journal
Volume:
20
Issue:
1
Article number:
194
Publication date:
2021-04-20
Acceptance date:
2021-04-08
DOI:
EISSN:
1475-2875
Pmid:
33879156

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