Effects of inhibitors of the lipo-oxygenase family of enzymes on the store-operated calcium current I(CRAC) in rat basophilic leukaemia cells.

Journal article

In non-excitable cells, the major Ca2+ entry pathway is the store-operated pathway in which emptying of intracellular Ca2+ stores activates Ca2+ channels in the plasma membrane. In many cell types, store-operated influx gives rise to a Ca2+-selective current called I(CRAC) (Ca2+ release-activated Ca2+ current). Using both the whole-cell patch clamp technique to measure I(CRAC) directly and fluorescent Ca2+ imaging, we have examined the role of the lipo-oxygenase pathway in the activation of s...

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Authors: Glitsch, M; Bakowski, D; Parekh, AB

• Publication status: Published
• Journal: Journal of physiology
• Volume: 539
• Issue: Pt 1
• Pages: 93-106
• Publication date: 2002-02-01
• DOI: 10.1113/jphysiol.2001.012826
• EISSN: 1469-7793
• ISSN: 0022-3751
• Language: English
• Keywords: Permeability; Basophils; Caffeic Acids; Lipoxygenase Inhibitors; Thapsigargin; Rats; Animals; Osmolar Concentration; Patch-Clamp Techniques; Calcium; Adenosine Triphosphate; Enzyme Inhibitors; Nordihydroguaiaretic Acid; Leukotrienes; Staurosporine; Tumor Cells, Cultured; Electric Conductivity; Intracellular Membranes; Sodium