Initial blood washout during organ procurement determines liver injury and function after preservation and reperfusion.

Journal article

Organ procurement is the first step toward effective liver preservation and comprises a thorough washout of blood components from the microvasculature. To study the efficacy of optimal blood washout of the liver, three groups were compared including low-pressure perfusion with UW-CSS (12 mmHg, group A), which is the routine method in clinical practice, high-pressure perfusion with UW-CSS (100 mmHg, group B) and low-pressure perfusion with modified UW solution (12 mmHg, group C). After procure...

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Authors: 't Hart, N; van der Plaats, A; Leuvenink, H; Wiersema-Buist, J; Olinga, P

• Publication status: Published
• Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
• Volume: 4
• Issue: 11
• Pages: 1836-1844
• Publication date: 2004-11-01
• DOI: 10.1111/j.1600-6143.2004.00580.x
• EISSN: 1600-6143
• ISSN: 1600-6135
• Language: English
• Keywords: Hepatocytes; Animals; Mitochondria, Liver; Glutathione; Organ Preservation Solutions; Tissue and Organ Harvesting; Organ Preservation; Reperfusion; Male; Raffinose; Rats; Rats, Wistar; Blood Physiological Phenomena; Hepatectomy; Adenosine; Microcirculation; Erythrocyte Count; Insulin; Allopurinol; Liver; Kinetics; Adenosine Triphosphate