Isoproterenol induces in vivo functional and metabolic abnormalities: similar to those found in the infarcted rat heart.

Journal article

Chronic isoproterenol administration produces a rapid, highly reproducible rodent model of cardiac hypertrophy. Yet, despite widespread use of this model, the effects of isoproterenol on in vivo cardiac function and substrate metabolism are unknown. Isoproterenol (5 mg.kg(-1).day(-1)) was infused for 7 days in male Wistar rats (n = 22). In vivo magnetic resonance imaging (MRI) showed that left ventricular mass increased by 37% and end-diastolic and systolic volumes increased by 33% and 73%, r...

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Authors: Heather, L; Catchpole, A; Stuckey, D; Cole, M; Carr, C

• Publication status: Published
• Journal: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society
• Volume: 60
• Issue: 3
• Pages: 31-39
• Publication date: 2009-09-01
• EISSN: 1899-1505
• ISSN: 0867-5910
• Language: English
• Keywords: Rats, Wistar; Fatty Acid Transport Proteins; Glucose Transporter Type 4; Blood Pressure; Adrenergic beta-Agonists; Heart Ventricles; Ventricular Function, Left; Magnetic Resonance Imaging, Cine; Isoproterenol; Hypertrophy, Left Ventricular; Glucose; Myocardial Infarction; Animals; Perfusion; Fatty Acids; Rats; Male; Disease Models, Animal