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Targeting bromodomains: epigenetic readers of lysine acetylation.

Abstract:

Lysine acetylation is a key mechanism that regulates chromatin structure; aberrant acetylation levels have been linked to the development of several diseases. Acetyl-lysine modifications create docking sites for bromodomains, which are small interaction modules found on diverse proteins, some of which have a key role in the acetylation-dependent assembly of transcriptional regulator complexes. These complexes can then initiate transcriptional programmes that result in phenotypic changes. The ...

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Publication status:
Published

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Publisher copy:
10.1038/nrd4286

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Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Structural Genomics Consortium
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Structural Genomics Consortium
Journal:
Nature reviews. Drug discovery
Volume:
13
Issue:
5
Pages:
337-356
Publication date:
2014-05-05
DOI:
EISSN:
1474-1784
ISSN:
1474-1776
URN:
uuid:f2fd6151-c82b-495e-85af-5479210b1670
Source identifiers:
463199
Local pid:
pubs:463199

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