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Recombinant Plasmodium vivax circumsporozoite surface protein allelic variants: antibody recognition by individuals from three communities in the Brazilian Amazon

Abstract:

Circumsporozoite protein (CSP) variants of P. vivax, besides having variations in the protein repetitive portion, can differ from each other in aspects such as geographical distribution, intensity of transmission, vectorial competence and immune response. Such aspects must be considered to P. vivax vaccine development. Therefore, we evaluated the immunogenicity of novel recombinant proteins corresponding to each of the three P. vivax allelic variants (VK210, VK247 and P. vivax-like) and of th...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41598-020-70893-3

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Role:
Author
ORCID:
0000-0002-9772-849X
Publisher:
Nature Research
Journal:
Scientific reports More from this journal
Volume:
10
Article number:
14020
Publication date:
2020-08-20
Acceptance date:
2020-08-02
DOI:
EISSN:
2045-2322
ISSN:
2045-2322
Pmid:
32820195
Language:
English
Keywords:
Pubs id:
1127682
Local pid:
pubs:1127682
Deposit date:
2020-08-27

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