Barbados Low Dose Aspirin Study in Pregnancy (BLASP): a randomised trial for the prevention of pre-eclampsia and its complications.

Rotchell, Y; Cruickshank, J; Gay, M; Griffiths, J; Stewart, A; Farrell, B; Ayers, S; Hennis, A; Grant, A; Duley, L; Collins, R

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Barbados Low Dose Aspirin Study in Pregnancy (BLASP): a randomised trial for the prevention of pre-eclampsia and its complications.

Abstract:: OBJECTIVE: To determine whether prophylactic, low dose controlled-release aspirin improves outcome for pregnant women and their babies in Barbados. DESIGN: Randomised placebo-controlled trial. SETTING: The Queen Elizabeth Hospital, Barbados. POPULATION: All women attending antenatal clinics between 12 and 32 weeks of gestation were eligible, if without specific contraindications to aspirin and unlikely to deliver immediately. METHODS: Randomisation was computer-generated in the antenatal clinic; 1822 women were allocated to receive 75 mg controlled-release aspirin and 1825 matching placebo. MAIN OUTCOME MEASURES: Proteinuric pre-eclampsia, other pregnancy-induced hypertension, pregnancy duration, birthweight, stillbirths and neonatal deaths, major neonatal events. RESULTS: All but three women from each group were followed up successfully. Forty-four percent were primigravid, and 8% had previous obstetric complications. There were no significant differences between the allocated treatment groups in the incidence of proteinuric pre-eclampsia (40 [2.2%] of those allocated aspirin, compared with 46 [2.5%] allocated placebo), of preterm delivery (255 [14.0%] vs 270 [14.8%]), of birthweight < 1500 g (32 [1.7%] vs 33 [1.8%]) or of stillbirth and neonatal death (44 [2.4%] vs 38 [2.1%]). Aspirin was not associated with excess risk of maternal or fetal bleeding. CONCLUSIONS: The results of this study in Barbados do not support the routine use of low dose aspirin for prevention of pre-eclampsia or its complications, confirming results of previous large trials in other settings.

Publication status:: Published

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APA Style

Rotchell, Y., Cruickshank, J., Gay, M., Griffiths, J., Stewart, A., Farrell, B., Ayers, S., Hennis, A., Grant, A., Duley, L., & Collins, R. (1998). Barbados Low Dose Aspirin Study in Pregnancy (BLASP): a randomised trial for the prevention of pre-eclampsia and its complications. British Journal of Obstetrics and Gynaecology, 105(3), 286–292.

MLA Style

Rotchell, Y., et al. “Barbados Low Dose Aspirin Study in Pregnancy (BLASP): a Randomised Trial for the Prevention of Pre-Eclampsia and Its Complications.” British Journal of Obstetrics and Gynaecology, vol. 105, no. 3, 1998, pp. 286–92.

Chicago Style

Rotchell, Y, J Cruickshank, M Gay, J Griffiths, A Stewart, B Farrell, S Ayers, et al. 1998. “Barbados Low Dose Aspirin Study in Pregnancy (BLASP): a Randomised Trial for the Prevention of Pre-Eclampsia and Its Complications.” In British Journal of Obstetrics and Gynaecology, 105:286–92.
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