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Coarse-grained simulations of the membrane-active antimicrobial Peptide maculatin 1.1.

Abstract:

Maculatin 1.1 (M1.1) is a membrane-active antimicrobial peptide (AMP) from an Australian tree frog that forms a kinked amphipathic alpha-helix in the presence of a lipid bilayer or bilayer-mimetic environment. To help elucidate its mechanism of membrane-lytic activity, we performed a total of approximately 8 micros of coarse-grained molecular dynamics (CG-MD) simulations of M1.1 in the presence of zwitterionic phospholipid membranes. Several systems were simulated in which the peptide/lipid r...

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Publication status:
Published

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Publisher copy:
10.1529/biophysj.108.128686
Journal:
Biophysical journal More from this journal
Volume:
95
Issue:
8
Pages:
3802-3815
Publication date:
2008-10-01
DOI:
EISSN:
1542-0086
ISSN:
0006-3495
Language:
English
Keywords:
Pubs id:
pubs:100573
UUID:
uuid:f2f5fb9a-2394-4f9f-9dd7-298a09137373
Local pid:
pubs:100573
Source identifiers:
100573
Deposit date:
2012-12-19

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