Effect of graft perfusion with two CD45 monoclonal antibodies on incidence of kidney allograft rejection.

Journal article

In a blind trial, 77 patients were randomised to receive first cadaver kidney allografts that had been perfused either with a pair of CD45 monoclonal antibodies (mAbs), in an attempt to reduce the immunogenicity of passenger leucocytes, or with control human albumin solution. No complications of mAb perfusion were observed. Patient and allograft survival were similar in both groups. Rejection episodes were recorded in 7 (18%) of the patient with mAb perfused allografts compared with 24 (63%) of the controls.

Authors: Brewer, Y; Palmer, A; Taube, D; Welsh, K; Bewick, M

• Publication status: Published
• Journal: Lancet
• Volume: 2
• Issue: 8669
• Pages: 935-937
• Publication date: 1989-10-01
• DOI: 10.1016/s0140-6736(89)90951-3
• EISSN: 1474-547X
• ISSN: 0140-6736
• Language: English
• Keywords: Antigens, Differentiation; Kidney Transplantation; Immunosuppression; Rats; Antigens, CD45; Evaluation Studies as Topic; Premedication; Animals; Incidence; Transplantation, Homologous; Histocompatibility Antigens; Perfusion; Creatinine; Randomized Controlled Trials as Topic; Humans; Dendritic Cells; Graft Rejection