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The mini-driver model of polygenic cancer evolution.

Abstract:

Much of cancer genetics research has focused on the identification of the most-important somatic mutations ('major drivers') that cause tumour growth. However, many mutations found in cancer might not be major drivers or 'passenger' mutations, but instead might have relatively weak tumour-promoting effects. Our aim is to highlight the existence of these mutations (termed 'mini drivers' herein), as multiple mini-driver mutations might substitute for a major-driver change, especially in the pre...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1038/nrc3999

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Institution:
University of Oxford
Department:
Oxford, MSD, Wtc Human Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDM, NDM Strategic
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDM, NDM Strategic
Role:
Author
Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature reviews. Cancer Journal website
Volume:
15
Issue:
11
Pages:
680-685
Publication date:
2015-11-05
DOI:
EISSN:
1474-1768
ISSN:
1474-175X
URN:
uuid:f2e613ab-99ee-4f31-bb32-6709d9ffbb1e
Source identifiers:
572837
Local pid:
pubs:572837

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