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Normobaric hypoxia impairs human cardiac energetics

Abstract:

Hypoxia causes left ventricular dysfunction in the human heart, but the biochemical mechanism is poorly understood. Here, we tested whether short-term normobaric hypoxia leads to changes in cardiac energetics and early cardiac dysfunction. Healthy male volunteers (n=12, age 24±2 yr) were exposed to normobaric hypoxia in a purpose-built hypoxic chamber. The partial pressure of oxygen during end-tidal expiration (P ETO 2) was kept between 50 and 60 mmHg, and peripheral oxygen saturation (SaO 2)...

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Publisher copy:
10.1096/fj.11-183426

Authors


Holloway, C More by this author
Cochlin, L More by this author
Codreanu, I More by this author
Fatemian, M More by this author
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Journal:
FASEB Journal
Volume:
25
Issue:
9
Pages:
3130-3135
Publication date:
2011-09-05
DOI:
EISSN:
1530-6860
ISSN:
0892-6638
URN:
uuid:f2e205c2-3e8a-43d5-abfc-c25ff7fc3864
Source identifiers:
179871
Local pid:
pubs:179871

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