Journal article
Adaptive copy number evolution in malaria parasites.
- Abstract:
-
Copy number polymorphism (CNP) is ubiquitous in eukaryotic genomes, but the degree to which this reflects the action of positive selection is poorly understood. The first gene in the Plasmodium folate biosynthesis pathway, GTP-cyclohydrolase I (gch1), shows extensive CNP. We provide compelling evidence that gch1 CNP is an adaptive consequence of selection by antifolate drugs, which target enzymes downstream in this pathway. (1) We compared gch1 CNP in parasites from Thailand (strong historica...
Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Access Document
- Files:
-
-
(Preview, Version of record, pdf, 477.4KB, Terms of use)
-
- Publisher copy:
- 10.1371/journal.pgen.1000243
Authors
Bibliographic Details
- Publisher:
- Public Library of Science
- Journal:
- PLoS genetics More from this journal
- Volume:
- 4
- Issue:
- 10
- Pages:
- e1000243
- Publication date:
- 2008-10-01
- DOI:
- EISSN:
-
1553-7404
- ISSN:
-
1553-7390
Item Description
- Language:
-
English
- Keywords:
-
- Pubs id:
-
pubs:18516
- UUID:
-
uuid:f2dabc8d-9628-425a-b063-923bab27ec56
- Local pid:
-
pubs:18516
- Source identifiers:
-
18516
- Deposit date:
-
2012-12-19
Terms of use
- Copyright holder:
- Nair et al
- Copyright date:
- 2008
- Notes:
- Copyright 2008 Nair et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
Metrics
If you are the owner of this record, you can report an update to it here: Report update to this record