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Journal article

Adaptive copy number evolution in malaria parasites.

Abstract:

Copy number polymorphism (CNP) is ubiquitous in eukaryotic genomes, but the degree to which this reflects the action of positive selection is poorly understood. The first gene in the Plasmodium folate biosynthesis pathway, GTP-cyclohydrolase I (gch1), shows extensive CNP. We provide compelling evidence that gch1 CNP is an adaptive consequence of selection by antifolate drugs, which target enzymes downstream in this pathway. (1) We compared gch1 CNP in parasites from Thailand (strong historica...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pgen.1000243

Authors


Barends, M More by this author
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National Institutes of Health More from this funder
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS genetics Journal website
Volume:
4
Issue:
10
Pages:
e1000243
Publication date:
2008-10-05
DOI:
EISSN:
1553-7404
ISSN:
1553-7390
URN:
uuid:f2dabc8d-9628-425a-b063-923bab27ec56
Source identifiers:
18516
Local pid:
pubs:18516

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