Ultrasound-enhanced systemic thrombolysis for acute ischemic stroke.

Journal article

BACKGROUND: Transcranial Doppler ultrasonography that is aimed at residual obstructive intracranial blood flow may help expose thrombi to tissue plasminogen activator (t-PA). Our objective was to determine whether ultrasonography can safely enhance the thrombolytic activity of t-PA. METHODS: We treated all patients who had acute ischemic stroke due to occlusion of the middle cerebral artery with intravenous t-PA within three hours after the onset of symptoms. The patients were randomly assig...

Expand abstract

Authors: Alexandrov, A; Molina, C; Grotta, J; Garami, Z; Ford, SR

• Publication status: Published
• Journal: New England journal of medicine
• Volume: 351
• Issue: 21
• Pages: 2170-2178
• Publication date: 2004-11-01
• DOI: 10.1056/nejmoa041175
• EISSN: 1533-4406
• ISSN: 0028-4793
• Language: English
• Keywords: Tissue Plasminogen Activator; Combined Modality Therapy; Injections, Intravenous; Humans; Thrombolytic Therapy; Ultrasonic Therapy; CLOTBUST Investigators; Infarction, Middle Cerebral Artery; Aged; Acute Disease; Fibrinolytic Agents; Brain Ischemia; Treatment Outcome; Ultrasonography, Doppler, Transcranial