Modelling the growth and stabilization of cerebral aneurysms.

Journal article

Experimental and theoretical guidance is needed to understand how the collagen fabric evolves during the development of aneurysms. In this paper, we model the development of an aneurysm as a cylindrical/spherical membrane subject to 1D enlargement; these conceptual models reflect the development of fusiform and saccular cerebral aneurysms. The mechanical response is attributed to the elastin and collagen. We introduce variables which define the elastin and collagen fibre concentration; these ...

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Authors: Watton, P; Ventikos, Y; Holzapfel, G

• Publication status: Published
• Journal: Mathematical medicine and biology : a journal of the IMA
• Volume: 26
• Issue: 2
• Pages: 133-164
• Publication date: 2009-06-01
• DOI: 10.1093/imammb/dqp001
• EISSN: 1477-8602
• ISSN: 1477-8599
• Language: English
• Keywords: Computer Simulation; Animals; Biomechanics; Fibroblasts; Cerebral Arteries; Time Factors; Hemodynamics; Humans; Models, Cardiovascular; Elasticity; Elastin; Intracranial Aneurysm; Weight-Bearing; Stress, Mechanical; Algorithms; Extracellular Matrix; Collagen