Journal article icon

Journal article

Basic fibroblast growth factor mediates transduction of mechanical signals when articular cartilage is loaded.

Abstract:

OBJECTIVE: To determine whether the basic fibroblast growth factor (bFGF) mediates signal transduction in articular cartilage in response to mechanical loading. METHODS: Articular cartilage from porcine metacarpophalangeal or knee joints was cyclically loaded (62.5-250N) for 2 minutes in the absence or presence of a bFGF receptor inhibitor, SB 402451 (250 nM). Activation of the extracellularly regulated kinase MAP kinase ERK was measured by Western blot analysis. Changes in protein synthesis...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1002/art.20047

Authors


Vincent, TL More by this author
Hermansson, MA More by this author
Hansen, UN More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Journal:
Arthritis and rheumatism
Volume:
50
Issue:
2
Pages:
526-533
Publication date:
2004-02-05
DOI:
EISSN:
1529-0131
ISSN:
0004-3591
URN:
uuid:f2cef09b-ec50-445c-8f53-2e8cc512ed27
Source identifiers:
226778
Local pid:
pubs:226778

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP