Basic fibroblast growth factor mediates transduction of mechanical signals when articular cartilage is loaded.

Journal article

OBJECTIVE: To determine whether the basic fibroblast growth factor (bFGF) mediates signal transduction in articular cartilage in response to mechanical loading. METHODS: Articular cartilage from porcine metacarpophalangeal or knee joints was cyclically loaded (62.5-250N) for 2 minutes in the absence or presence of a bFGF receptor inhibitor, SB 402451 (250 nM). Activation of the extracellularly regulated kinase MAP kinase ERK was measured by Western blot analysis. Changes in protein synthesis...

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Authors: Vincent, T; Hermansson, M; Hansen, U; Amis, A; Saklatvala, J

• Publication status: Published
• Journal: Arthritis and rheumatism
• Volume: 50
• Issue: 2
• Pages: 526-533
• Publication date: 2004-02-01
• DOI: 10.1002/art.20047
• EISSN: 1529-0131
• ISSN: 0004-3591
• Language: English
• Keywords: Weight-Bearing; Signal Transduction; Tissue Inhibitor of Metalloproteinase-1; Animals; Stifle; Blotting, Western; Stress, Mechanical; Chondrocytes; Fibroblast Growth Factor 2; Pyrimidines; Cartilage, Articular; Swine; Mitogen-Activated Protein Kinases; Receptors, Fibroblast Growth Factor