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Different mechanisms may generate sustained hypertonic and rhythmic bursting muscle activity in idiopathic dystonia.

Abstract:

Despite that deep brain stimulation (DBS) of the globus pallidus internus (GPi) is emerging as the favored intervention for patients with medically intractable dystonia, the pathophysiological mechanisms of dystonia are largely unclear. In eight patients with primary dystonia who were treated with bilateral chronic pallidal stimulation, we correlated symptom-related electromyogram (EMG) activity of the most affected muscles with the local field potentials (LFPs) recorded from the globus palli...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD
Role:
Author
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Journal:
Experimental neurology
Volume:
198
Issue:
1
Pages:
204-213
Publication date:
2006-03-05
DOI:
EISSN:
1090-2430
ISSN:
0014-4886
URN:
uuid:f2c95be4-f409-42ce-b097-d2e959913e2b
Source identifiers:
148053
Local pid:
pubs:148053

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