Different mechanisms may generate sustained hypertonic and rhythmic bursting muscle activity in idiopathic dystonia.

Journal article

Despite that deep brain stimulation (DBS) of the globus pallidus internus (GPi) is emerging as the favored intervention for patients with medically intractable dystonia, the pathophysiological mechanisms of dystonia are largely unclear. In eight patients with primary dystonia who were treated with bilateral chronic pallidal stimulation, we correlated symptom-related electromyogram (EMG) activity of the most affected muscles with the local field potentials (LFPs) recorded from the globus palli...

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Authors: Liu, X; Yianni, J; Wang, S; Bain, P; Stein, J

• Publication status: Published
• Journal: Experimental neurology
• Volume: 198
• Issue: 1
• Pages: 204-213
• Publication date: 2006-03-01
• DOI: 10.1016/j.expneurol.2005.11.018
• EISSN: 1090-2430
• ISSN: 0014-4886
• Language: English
• Keywords: Adult; Magnetic Resonance Imaging; Male; Deep Brain Stimulation; Electromyography; Humans; Female; Globus Pallidus; Middle Aged; Functional Laterality; Muscle, Skeletal; Aged; Periodicity; Dystonic Disorders