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PTEN: tumour suppressor, multifunctional growth regulator and more.

Abstract:

The tumour suppressor gene PTEN is mutated in a wide range of human cancers at a frequency roughly comparable with p53. In addition, germline PTEN mutations are associated with several dominant growth disorders. The molecular and cellular basis of these disorders has been elucidated by detailed in vivo genetic analysis in model organisms, in particular the fruit fly and mouse. Studies in the fly have shown that PTEN's growth regulatory functions are primarily mediated via its lipid phosphatas...

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Publication status:
Published

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Publisher copy:
10.1093/hmg/ddg288

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
Journal:
Human molecular genetics
Volume:
12 Spec No 2
Issue:
REV. ISS. 2
Pages:
R239-R248
Publication date:
2003-10-05
DOI:
EISSN:
1460-2083
ISSN:
0964-6906
URN:
uuid:f2c21959-1d2b-4953-acb2-4638572d147d
Source identifiers:
114075
Local pid:
pubs:114075

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