Angiopoietin-1 Treatment Reduces Inflammation but Does Not Prevent Ventilator-Induced Lung Injury

Journal article

Ang-1 treatment downregulates pulmonary inflammation, VEGF and Ang-2 expression but does not protect against vascular leakage and impaired gas exchange induced by HVT-ventilation.

Authors: Hegeman, MA; Hennus, MP; van Meurs, M; Cobelens, PM; Kavelaars, A

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Public Library of Science
• Journal: PLoS ONE
• Volume: 5
• Issue: 12
• Pages: e15653-e15653
• Publication date: 2010-12-14
• DOI: 10.1371/journal.pone.0015653
• EISSN: 1932-6203
• ISSN: 1932-6203
• Language: English
• Keywords: Endocrinology; Medicine; Pharmacology; Receptor; Respiratory system; Angiopoietin; Lung; Inflammation; Angiopoietin receptor; Immunology; Internal medicine; Anesthesia; Mechanical ventilation; Vascular endothelial growth factor; Tidal volume