Perceptions of equipoise are crucial to trial participation: a qualitative study of men in the ProtecT study.

Journal article

Recruitment to trials is known to be difficult. Previous research suggests that a crucial factor may be participants' difficulty with the concept of randomization. This study explored patients' perceptions of randomization and reasons for consent or refusal to participate in the ProtecT study (a randomized trial of surgery, radiotherapy, and monitoring for localized prostate cancer). In-depth interviews were conducted with 21 men diagnosed with localized prostate cancer who were invited to pa...

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Authors: Mills, N; Donovan, J; Smith, M; Jacoby, A; Neal, D

• Publication status: Published
• Journal: Controlled clinical trials
• Volume: 24
• Issue: 3
• Pages: 272-282
• Publication date: 2003-06-01
• DOI: 10.1016/s0197-2456(03)00020-5
• ISSN: 0197-2456
• Language: English
• Keywords: Middle Aged; Patient Selection; Treatment Refusal; Humans; Research Subjects; Great Britain; Aged; Randomized Controlled Trials as Topic; Comprehension; Patient Participation; Male; Interviews as Topic; Prostatic Neoplasms; Patient Compliance