The human immune response to Dengue virus is dominated by highly cross-reactive antibodies endowed with neutralizing and enhancing activity.

Journal article

Antibodies protect against homologous Dengue virus (DENV) infection but can precipitate severe dengue by promoting heterotypic virus entry via Fcγ receptors (FcγR). We immortalized memory B cells from individuals after primary or secondary infection and analyzed anti-DENV monoclonal antibodies (mAbs) thus generated. MAbs to envelope (E) protein domain III (DIII) were either serotype specific or cross-reactive and potently neutralized DENV infection. DI/DII- or viral membrane protein prM-react...

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Authors: Beltramello, M; Williams, K; Simmons, C; Macagno, A; Simonelli, L

• Publication status: Published
• Journal: Cell host and microbe
• Volume: 8
• Issue: 3
• Pages: 271-283
• Publication date: 2010-09-01
• DOI: 10.1016/j.chom.2010.08.007
• EISSN: 1934-6069
• ISSN: 1931-3128
• Language: English
• Keywords: Cross Reactions; Immunoblotting; Dengue Virus; Antibodies, Monoclonal; Humans; B-Lymphocytes; Enzyme-Linked Immunosorbent Assay; Receptors, IgG; Serotyping; Antibody-Dependent Enhancement; Blotting, Western; Animals; Neutralization Tests; Antibodies, Viral; Dengue; Antibodies, Neutralizing; Viral Envelope Proteins; Mice; Viral Nonstructural Proteins