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Cyclooxygenase-2 (Cox-2) in injured human nerve and a rat model of nerve injury.

Abstract:

Inflammation associated with nerve injury produces a number of pathogenic chemical mediators of which prostanoids are a potent component. Cyclooxygenases (Cox-1 and Cox-2) are the enzymes responsible for prostanoid production. We have investigated Cox-2 immunoreactivity (Cox-2-IR) and glial activation in human injured (n = 16) and uninjured (n = 8) nerves and in the chronic constriction injury (CCI) model of nerve injury in the rat, using immunohistological and autoradiographic methods. Tissu...

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Publication status:
Published

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Authors


Durrenberger, PF More by this author
Chessell, IP More by this author
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Journal:
Journal of the peripheral nervous system : JPNS
Volume:
9
Issue:
1
Pages:
15-25
Publication date:
2004-03-05
DOI:
EISSN:
1529-8027
ISSN:
1085-9489
URN:
uuid:f2a6b10e-b529-455b-9a30-61e7146c7ca2
Source identifiers:
32623
Local pid:
pubs:32623

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