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High-efficiency gene transfer into nontransformed cells: utility for studying gene regulation and analysis of potential therapeutic targets.

Abstract:

The elucidation of the signalling pathways involved in inflammatory diseases, such as rheumatoid arthritis, could provide long sought after targets for therapeutic intervention. Gene regulation is complex and varies depending on the cell type, as well as the signal eliciting gene activation. However, cells from certain lineages, such as macrophages, are specialised to degrade exogenous material and consequently do not easily transfect. Methods for high-efficiency gene transfer into primary ce...

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Publisher copy:
10.1186/ar560

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Journal:
Arthritis research
Volume:
4 Suppl 3
Pages:
S215-S225
Publication date:
2002-01-01
DOI:
EISSN:
1465-9913
ISSN:
1465-9905
Source identifiers:
223481
Language:
English
Keywords:
Pubs id:
pubs:223481
UUID:
uuid:f2a67e03-73ac-4128-a75a-20d954cfdaa2
Local pid:
pubs:223481
Deposit date:
2012-12-19

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