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Journal article

Estimation of the total parasite biomass in acute falciparum malaria from plasma PfHRP2.

Abstract:

BACKGROUND: In falciparum malaria sequestration of erythrocytes containing mature forms of Plasmodium falciparum in the microvasculature of vital organs is central to pathology, but quantitation of this hidden sequestered parasite load in vivo has not previously been possible. The peripheral blood parasite count measures only the circulating, relatively non-pathogenic parasite numbers. P. falciparum releases a specific histidine-rich protein (PfHRP2) into plasma. Quantitative measurement of ...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Thailand/Laos MOP
Desakorn, V More by this author
Pongtavornpinyo, W More by this author
Sahassananda, D More by this author
Silamut, K More by this author
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Journal:
PLoS medicine
Volume:
2
Issue:
8
Pages:
e204
Publication date:
2005-08-05
DOI:
EISSN:
1549-1676
ISSN:
1549-1277
URN:
uuid:f2a5ac5a-1c28-46de-afb2-6dd16d5780ab
Source identifiers:
22724
Local pid:
pubs:22724

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