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Maintenance of HIV-specific CD4+ T cell help distinguishes HIV-2 from HIV-1 infection.

Abstract:

Unlike HIV-1-infected people, most HIV-2-infected subjects maintain a healthy CD4+ T cell count and a strong HIV-specific CD4+ T cell response. To define the cellular immunological correlates of good prognosis in HIV-2 infection, we conducted a cross-sectional study of HIV Gag-specific T cell function in HIV-1- and HIV-2-infected Gambians. Using cytokine flow cytometry and lymphoproliferation assays, we show that HIV-specific CD4+ T cells from HIV-2-infected individuals maintained proliferati...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Molecular Medicine
Role:
Author
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Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
176
Issue:
11
Pages:
6973-6981
Publication date:
2006-06-05
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:f2a3e7d2-9d53-4c08-b666-45d76d4c451f
Source identifiers:
8851
Local pid:
pubs:8851

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