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Transcription factors FOXA1 and FOXA2 maintain dopaminergic neuronal properties and control feeding behavior in adult mice.

Abstract:

Midbrain dopaminergic (mDA) neurons are implicated in cognitive functions, neuropsychiatric disorders, and pathological conditions; hence understanding genes regulating their homeostasis has medical relevance. Transcription factors FOXA1 and FOXA2 (FOXA1/2) are key determinants of mDA neuronal identity during development, but their roles in adult mDA neurons are unknown. We used a conditional knockout strategy to specifically ablate FOXA1/2 in mDA neurons of adult mice. We show that deletion ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1073/pnas.1503911112

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Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
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Funding agency for:
Kaufmann, AK
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Funding agency for:
Brimblecombe, KR
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Funding agency for:
Threlfell, S
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Funding agency for:
Magill, PJ
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Publisher:
National Academy of Sciences Publisher's website
Journal:
Proceedings of the National Academy of Sciences of the United States of America Journal website
Volume:
112
Issue:
35
Pages:
E4929-E4938
Publication date:
2015-09-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:f29ef729-2094-4610-8062-734e74a7b615
Source identifiers:
539449
Local pid:
pubs:539449
Language:
English
Keywords:

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