Journal article

Transcription factors FOXA1 and FOXA2 maintain dopaminergic neuronal properties and control feeding behavior in adult mice.

Abstract:: Midbrain dopaminergic (mDA) neurons are implicated in cognitive functions, neuropsychiatric disorders, and pathological conditions; hence understanding genes regulating their homeostasis has medical relevance. Transcription factors FOXA1 and FOXA2 (FOXA1/2) are key determinants of mDA neuronal identity during development, but their roles in adult mDA neurons are unknown. We used a conditional knockout strategy to specifically ablate FOXA1/2 in mDA neurons of adult mice. We show that deletion ...
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Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Pristerà, A., Lin, W., Kaufmann, A., Brimblecombe, K., Threlfell, S., Dodson, P., Magill, P., Fernandes, C., Cragg, S., & Ang, S. (2015). Transcription factors FOXA1 and FOXA2 maintain dopaminergic neuronal properties and control feeding behavior in adult mice. Proceedings of the National Academy of Sciences of the United States of America, 112(35), E4929–E4938.

MLA Style

Pristerà, A., et al. “Transcription Factors FOXA1 and FOXA2 Maintain Dopaminergic Neuronal Properties and Control Feeding Behavior in Adult Mice.” Proceedings of the National Academy of Sciences of the United States of America, vol. 112, no. 35, National Academy of Sciences, 2015, pp. E4929–E4938.

Chicago Style

Pristerà, A, W Lin, A Kaufmann, K Brimblecombe, S Threlfell, P Dodson, P Magill, C Fernandes, S Cragg, and S Ang. 2015. “Transcription Factors FOXA1 and FOXA2 Maintain Dopaminergic Neuronal Properties and Control Feeding Behavior in Adult Mice.” Proceedings of the National Academy of Sciences of the United States of America 112 (35): E4929–E4938.
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Publisher copy:: 10.1073/pnas.1503911112

Authors

+ Pristerà, A More by this author

Role:

Author

+ Lin, W More by this author

Role:

Author

+ Kaufmann, A More by this author

Institution:

University of Oxford

Division:

MSD

Department:

Pharmacology

Role:

Author

+ Brimblecombe, K More by this author

Institution:

University of Oxford

Division:

MSD

Department:

Physiology Anatomy & Genetics

Role:

Author

+ Threlfell, S More by this author

Institution:

University of Oxford

Division:

MSD

Department:

Physiology Anatomy & Genetics

Role:

Author

More authors...

Funding

+ Parkinson's UK More from this funder

Funding agency for:

Brimblecombe, K

Threlfell, S

Magill, P

Cragg, S

Grant:

H-1003

MC_UU_12020/5

+ Medical Research Council More from this funder

Funding agency for:

Kaufmann, A

Magill, P

Grant:

MC_UU_12020/5

+ Wellcome Trust More from this funder

+ Francis Crick Institute More from this funder

Bibliographic Details

Publisher:: National Academy of Sciences
Journal:: Proceedings of the National Academy of Sciences of the United States of America More from this journal
Volume:: 112
Issue:: 35
Pages:: E4929-E4938
Publication date:: 2015-09-01
DOI:: 10.1073/pnas.1503911112
EISSN:: 1091-6490
ISSN:: 0027-8424

Item Description

Language:: English
Keywords:: feeding

burst firing

FOXA2

FOXA1

dopamine
Pubs id:: pubs:539449
UUID:: uuid:f29ef729-2094-4610-8062-734e74a7b615
Local pid:: pubs:539449
Source identifiers:: 539449
Deposit date:: 2015-11-24

Terms of use

Copyright holder:: Pristerà et al
Copyright date:: 2015

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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