Signal transduction pathways that function in both development and innate immunity.

Journal article

Abstract:: C. elegans is developing in importance as a model for innate immunity. Several signaling pathways are known to be required for immune responses to a diverse range of pathogens, including the insulin signaling, p38 MAP kinase and transforming growth factor-beta pathways. These pathways also have roles during development, which can complicate the analysis of their functions in immunity. Recent studies have suggested that immunity in C. elegans is integrated across the organism by both paracrine and neuronal communication, showing the complexity of the immune system in this organism.

Journal:: Developmental dynamics : an official publication of the American Association of Anatomists More from this journal
Volume:: 239
Issue:: 5
Pages:: 1330-1336
Publication date:: 2010-05-01
DOI:: 10.1002/dvdy.22232
EISSN:: 1097-0177
ISSN:: 1058-8388

Language:: English
Keywords:: Signal Transduction

Immunity, Innate

Animals

Growth and Development

Immune System

Caenorhabditis elegans
Pubs id:: pubs:202873
UUID:: uuid:f29a3cfc-2685-466f-9636-b79fb730406f
Local pid:: pubs:202873
Source identifiers:: 202873
Deposit date:: 2012-12-19
ARK identifier:: ark:/29072/ora_f29a3cfc2685466f9636b79fb730406f

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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