Journal article icon

Journal article

Cis-acting sequences regulating expression of the human alpha-globin cluster lie within constitutively open chromatin.

Abstract:

Current models suggest that tissue-specific genes are arranged in discrete, independently controlled segments of chromatin referred to as regulatory domains. Transition from a closed to open chromatin structure may be an important step in the regulation of gene expression. To determine whether the human alpha-globin cluster, like the beta-globin cluster, lies within a discrete, erythroid-specific domain, we have examined the long-range genomic organization and chromatin structure around this ...

Expand abstract
Publication status:
Published

Actions


Access Document


Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Molecular Medicine, Biomedical Research
Vickers, MA More by this author
Simmons, DL More by this author
Craddock, CF More by this author
Expand authors...
Journal:
Cell
Volume:
69
Issue:
5
Pages:
781-793
Publication date:
1992-05-05
DOI:
EISSN:
1097-4172
ISSN:
0092-8674
URN:
uuid:f2964de8-c58d-43c3-a832-b856e407e6c7
Source identifiers:
33112
Local pid:
pubs:33112

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP