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Cis-acting sequences regulating expression of the human alpha-globin cluster lie within constitutively open chromatin.

Abstract:

Current models suggest that tissue-specific genes are arranged in discrete, independently controlled segments of chromatin referred to as regulatory domains. Transition from a closed to open chromatin structure may be an important step in the regulation of gene expression. To determine whether the human alpha-globin cluster, like the beta-globin cluster, lies within a discrete, erythroid-specific domain, we have examined the long-range genomic organization and chromatin structure around this ...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
Journal:
Cell More from this journal
Volume:
69
Issue:
5
Pages:
781-793
Publication date:
1992-05-01
DOI:
EISSN:
1097-4172
ISSN:
0092-8674
Language:
English
Keywords:
Pubs id:
pubs:33112
UUID:
uuid:f2964de8-c58d-43c3-a832-b856e407e6c7
Local pid:
pubs:33112
Source identifiers:
33112
Deposit date:
2012-12-19

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