Maintenance of basal plasma glucose and insulin concentrations in maturity-onset diabetes.

Journal article

Normal and mildly diabetic subjects each have their own "set" of basal plasma glucose and insulin concentrations. Diabetic patients have raised basal plasma glucose, with low-normal basal plasma C-peptide concentrations. Restoring normal glucose levels in mild diabetes by an insulin infusion further reduces the C-peptide concentration, but both the plasma glucose and the C-peptide return to their "set" level when the insulin is withdrawn. These results accord with the action of beta cells and liver in a negative feedback loop that maintains basal plasma glucose and insulin concentrations.

Authors: Holman, R; Turner, R

• Publication status: Published
• Journal: Diabetes
• Volume: 28
• Issue: 3
• Pages: 227-230
• Publication date: 1979-03-01
• DOI: 10.2337/diab.28.3.227
• EISSN: 1939-327X
• ISSN: 0012-1797
• Language: English
• Keywords: Humans; C-Peptide; Insulin; Diabetes Mellitus; Middle Aged; Adult; Blood Glucose