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Use of genome wide expression profiles in analysis of T cell dysfunction in Hepatitis C virus infection

Abstract:

During the course of infection with chronic pathogens such as Hepatitis C virus (HCV), Hepatitis B virus (HBV) and HIV, virus-specific CD8+ T cells differentiate into heterogeneous dysfunctional subpopulations. Advances in multi-parameter flow cytometry have allowed these subpopulations to be further classified into classes of exhausted T cells, primarily by their expression of multiple inhibitory receptors. However, the exact phenotype of CD8+ T cel...

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Oxford college:
Green Templeton College
Role:
Author

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Role:
Supervisor
Role:
Supervisor
Publication date:
2014
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
UUID:
uuid:f28b67d7-287d-4594-a2d1-161f35e9c5a2
Local pid:
ora:11662
Deposit date:
2015-06-12

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