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Time-dependent changes in donor brain death related processes.

Abstract:

Donor brain death (BD) affects kidney function and survival after transplantation. Studies on brain dead kidney donors indicate that, besides inflammation and coagulation, cytoprotective gene expression is activated as well. Here, we evaluated in a time-course experiment progression of these renal BD-related processes. Animals were sacrificed 0.5, 1, 2 or 4 h after BD and compared to sham-operated controls. Proinflammatory genes (E-selectin, MCP-1, II-6) were massively up-regulated (p < 0....

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Publication status:
Published

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Authors


Schuurs, TA More by this author
Morariu, AM More by this author
Ottens, PJ More by this author
't Hart, NA More by this author
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Journal:
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Volume:
6
Issue:
12
Pages:
2903-2911
Publication date:
2006-12-05
DOI:
EISSN:
1600-6143
ISSN:
1600-6135
URN:
uuid:f28b024a-7c53-46a1-8274-c900da0731fd
Source identifiers:
190968
Local pid:
pubs:190968

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