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Pause sites promote transcriptional termination of mammalian RNA polymerase II.

Abstract:

Polymerase II (Pol II) transcriptional termination depends on two independent genetic elements: poly(A) signals and downstream terminator sequences. The latter may either promote cotranscriptional RNA cleavage or pause elongating Pol II. We demonstrate that the previously characterized MAZ4 pause element promotes Pol II termination downstream of a poly(A) signal, dependent on both the proximity of the pause site and poly(A) signal and the strength of the poly(A) signal. The 5'-->3' exonucl...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Journal:
Molecular and cellular biology
Volume:
26
Issue:
10
Pages:
3986-3996
Publication date:
2006-05-05
DOI:
EISSN:
1098-5549
ISSN:
0270-7306
URN:
uuid:f289fd4d-c54e-492e-bfde-bf72c106ce79
Source identifiers:
13769
Local pid:
pubs:13769

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