Maintaining memory of silencing at imprinted differentially methylated regions.

Journal article

Abstract:: Imprinted genes are an exceptional cluster of genes which are expressed in a parent-of-origin dependent fashion. This allele-specific expression is dependent on differential DNA methylation which is established in the parental germlines in a sex-specific manner. The DNA methylation imprint is accompanied by heterochromatin modifications which must be continuously maintained through development. This review summarises the factors which are important for protecting the epigenetic modifications at imprinted differentially methylated regions (DMRs), including PGC7, ZFP57 and the ATRX/Daxx/H3.3 complex. We discuss how these factors maintain heterochromatin silencing, not only at imprinted DMRs, but also other heterochromatic regions in the genome.

Files:: Maintaining memory of silencing at imprinted differentially me...

(Preview, Version of record, pdf, 814.8KB, Terms of use)

Publisher:: Springer International Publishing
Journal:: Cellular and molecular life sciences : CMLS More from this journal
Publication date:: 2016-01-01
Acceptance date:: 2016-02-04
DOI:: 10.1007/s00018-016-2157-6
EISSN:: 1420-9071
ISSN:: 1420-682X

Language:: English
Keywords:: Zfp57

Daxx

H3.3

ATRX

heterochromatin

PGC7

genomic imprinting
Pubs id:: pubs:606558
UUID:: uuid:f284a902-d54b-4f92-b246-241e74b95645
Local pid:: pubs:606558
Source identifiers:: 606558
Deposit date:: 2016-02-26
ARK identifier:: ark:/29072/ora_f284a902d54b4f92b246241e74b95645

Copyright holder:: Voon and Gibbons
Notes:: Copyright © The Author(s) 2016. This article is distributed under the terms of the
Creative Commons Attribution 4.0 International License (http://
creativecommons.org/licenses/by/4.0/), which permits unrestricted
use, distribution, and reproduction in any medium, provided you give
appropriate credit to the original author(s) and the source, provide a
link to the Creative Commons license, and indicate if changes were
made.

If you are the owner of this record, you can report an update to it here: Report update to this record