Journal article

Investigation of the SSRI augmentation properties of 5-HT(2) receptor antagonists using in vivo microdialysis.

Abstract:: Recent evidence that 5-HT(2) receptors exert a negative influence on central 5-hydroxytryptamine (5-HT) neurones suggests that 5-HT(2) receptor antagonists may augment the effects of serotonin selective reuptake inhibitors (SSRIs). The present study investigated whether pre-treatment with 5-HT(2) receptor antagonists enhances the effect of SSRI administration on hippocampal extracellular 5-HT of freely moving rats. Administration of the SSRI citalopram at a low (2mg kg(-1)) and higher (4 mg kg(-1)) dose, increased dialysate 5-HT by 5- and 8-fold, respectively. Pre-treatment with the 5-HT(2) receptor antagonist ketanserin (4 mg kg(-1)) augmented the effect of 4 mg kg(-1) but not 2mg kg(-1) citalopram. The effect of 4 mg kg(-1) citalopram was also augmented by pre-treatment with either the 5-HT(2C) receptor antagonist SB 242084 (0.5mg kg(-1)) or the 5-HT(2A) receptor antagonist MDL 100907 (0.5mg kg(-1)). As with citalopram, fluoxetine elevated dialysate 5-HT at both a low (5mg kg(-1)) and higher (20mg kg(-1)) dose. However, neither dose of fluoxetine was augmented by ketanserin (4 mg kg(-1)). These results confirm recent findings that 5-HT(2) receptor antagonists augment the effect of citalopram on extracellular 5-HT, and indicate the involvement of 5-HT(2C) and possibly 5-HT(2A) receptors. The lack of augmentation of fluoxetine might reflect the intrinsic 5-HT(2) receptor antagonist properties of this drug.

Publication status:: Published

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APA Style

Boothman, L., Mitchell, S. N., & Sharp, T. (2006). Investigation of the SSRI augmentation properties of 5-HT(2) receptor antagonists using in vivo microdialysis. Neuropharmacology, 50(6), 726–732.

MLA Style

Boothman, L, et al. “Investigation of the SSRI Augmentation Properties of 5-HT(2) Receptor Antagonists Using in Vivo Microdialysis.” Neuropharmacology, vol. 50, no. 6, 2006, pp. 726–32.

Chicago Style

Boothman, L, SN Mitchell, and T Sharp. 2006. “Investigation of the SSRI Augmentation Properties of 5-HT(2) Receptor Antagonists Using in Vivo Microdialysis.” Neuropharmacology 50 (6): 726–32.
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Publisher copy:: 10.1016/j.neuropharm.2005.11.020

Authors

+ Boothman, L More by this author

Role:: Author

+ Mitchell, SN More by this author

Role:: Author

+ Sharp, T More by this author

Institution:: University of Oxford
Division:: MSD
Department:: Pharmacology
Role:: Author

Journal:: Neuropharmacology More from this journal
Volume:: 50
Issue:: 6
Pages:: 726-732
Publication date:: 2006-05-01
DOI:: 10.1016/j.neuropharm.2005.11.020
EISSN:: 1873-7064
ISSN:: 0028-3908

Language:: English
Keywords:: Drug Synergism

Serotonin Antagonists

Analysis of Variance

Wakefulness

Rats

Hippocampus

Microdialysis

Serotonin 5-HT2 Receptor Antagonists

Serotonin

Rats, Sprague-Dawley

Chromatography, High Pressure Liquid

Dose-Response Relationship, Drug

Male

Serotonin Uptake Inhibitors

Animals
Pubs id:: pubs:185222
UUID:: uuid:f2820542-9924-43e6-b464-102a2e610d8d
Local pid:: pubs:185222
Source identifiers:: 185222
Deposit date:: 2012-12-19
ARK identifier:: ark:/29072/ora_f2820542992443e6b464102a2e610d8d

Terms of use

Copyright date:: 2006

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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