Investigation of the SSRI augmentation properties of 5-HT(2) receptor antagonists using in vivo microdialysis.

Journal article

Recent evidence that 5-HT(2) receptors exert a negative influence on central 5-hydroxytryptamine (5-HT) neurones suggests that 5-HT(2) receptor antagonists may augment the effects of serotonin selective reuptake inhibitors (SSRIs). The present study investigated whether pre-treatment with 5-HT(2) receptor antagonists enhances the effect of SSRI administration on hippocampal extracellular 5-HT of freely moving rats. Administration of the SSRI citalopram at a low (2mg kg(-1)) and higher (4 mg k...

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Authors: Boothman, L; Mitchell, SN; Sharp, T

• Publication status: Published
• Journal: Neuropharmacology
• Volume: 50
• Issue: 6
• Pages: 726-732
• Publication date: 2006-05-01
• DOI: 10.1016/j.neuropharm.2005.11.020
• EISSN: 1873-7064
• ISSN: 0028-3908
• Language: English
• Keywords: Rats, Sprague-Dawley; Microdialysis; Hippocampus; Male; Rats; Wakefulness; Chromatography, High Pressure Liquid; Serotonin; Serotonin Antagonists; Analysis of Variance; Drug Synergism; Serotonin 5-HT2 Receptor Antagonists; Dose-Response Relationship, Drug; Serotonin Uptake Inhibitors; Animals