HLA-typing in multiple sclerosis sibling pairs.

Journal article

40 sibling pairs with multiple sclerosis (MS) from 36 families were typed for HLA antigens. The frequency of haplotypic sharing in this population-based group of patients differed little from that expected by chance. The findings are strong evidence against a single MS susceptibility gene closely linked to HLA. This evidence conflicts with previous pooled data which have been considered to prove the existence of such a gene and questions the validity of such data in HLA family studies. © 1982.

Authors: Ebers, G; Paty, D; Stiller, C; Nelson, R; Seland, T

• Publication status: Published
• Journal: Lancet
• Volume: 2
• Issue: 8289
• Pages: 88-90
• Publication date: 1982-07-01
• DOI: 10.1016/s0140-6736(82)91702-0
• EISSN: 1474-547X
• ISSN: 0140-6736
• Language: English
• Keywords: Risk; Humans; HLA Antigens; Optic Neuritis; Multiple Sclerosis; Genetic Linkage; Disease Susceptibility