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Polycomblike 2 facilitates the recruitment of PRC2 Polycomb group complexes to the inactive X chromosome and to target loci in embryonic stem cells.

Abstract:

Polycomb group (PcG) proteins play an important role in the control of developmental gene expression in higher organisms. In mammalian systems, PcG proteins participate in the control of pluripotency, cell fate, cell cycle regulation, X chromosome inactivation and parental imprinting. In this study we have analysed the function of the mouse PcG protein polycomblike 2 (Pcl2), one of three homologues of the Drosophila Polycomblike (Pcl) protein. We show that Pcl2 is expressed at high levels dur...

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Publication status:
Published

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Publisher copy:
10.1242/dev.053652

Authors


Casanova, M More by this author
Preissner, T More by this author
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Journal:
Development (Cambridge, England)
Volume:
138
Issue:
8
Pages:
1471-1482
Publication date:
2011-04-05
DOI:
EISSN:
1477-9129
ISSN:
0950-1991
URN:
uuid:f2798746-bf94-4a45-b4f2-114954660b52
Source identifiers:
120215
Local pid:
pubs:120215

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