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Inhibitors of type IV phosphodiesterases reduce the toxicity of MPTP in substantia nigra neurons in vivo.

Abstract:

The neuropathology of Parkinson's disease is characterized by the degeneration of dopaminergic neurons in the substantia nigra. We have recently shown that the activation of protein kinase A improves the survival of dopaminergic neurons in culture and, furthermore, protects them from the dopaminergic neurotoxin, 1-methyl-4-phenylpyridinium ion (MPP+) in vitro. We have now analysed the potential of phosphodiesterase inhibitors to increase cAMP levels in dopaminergic neurons, to improve their s...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
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Journal:
The European journal of neuroscience
Volume:
7
Issue:
12
Pages:
2431-2440
Publication date:
1995-12-05
DOI:
EISSN:
1460-9568
ISSN:
0953-816X
URN:
uuid:f2743b24-b523-44d4-a251-7a4d0e2ad15b
Source identifiers:
107392
Local pid:
pubs:107392

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