Parafibromin is a nuclear protein with a functional monopartite nuclear localization signal.

Journal article

Parafibromin is a nuclear protein with a tumour suppressor role in the development of non-hereditary and hereditary parathyroid carcinomas, and the hyperparathyroidism-jaw tumour (HPT-JT) syndrome, which is associated with renal and uterine tumours. Nuclear localization signal(s), (NLS(s)), of the 61 kDa parafibromin remain to be defined. Utilization of computer-prediction programmes, identified five NLSs (three bipartite (BP) and two monopartite (MP)). To investigate their functionality, wil...

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Authors: Bradley, K; Bowl, MR; Williams, SE; Ahmad, B; Partridge, C

• Publication status: Published
• Journal: Oncogene
• Volume: 26
• Issue: 8
• Pages: 1213-1221
• Publication date: 2007-02-01
• DOI: 10.1038/sj.onc.1209893
• EISSN: 1476-5594
• ISSN: 0950-9232
• Language: English
• Keywords: Cell Nucleus; Nuclear Localization Signals; Amino Acid Sequence; Sequence Alignment; Molecular Sequence Data; Conserved Sequence; Animals; Blotting, Western; COS Cells; Green Fluorescent Proteins; Evolution, Molecular; Tumor Suppressor Proteins; Cercopithecus aethiops; Protein Structure, Tertiary; Nuclear Proteins; Mutation; Humans