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Journal article

HLA-B*35-restricted CD8 T cell epitopes in the antigen 85 complex of Mycobacterium tuberculosis.

Abstract:

Few target epitopes have been described for human CD8 T lymphocytes in antigens of Mycobacterium tuberculosis. By use of a reverse immunogenetics approach, 23 motif-bearing peptides of the Ag85 complex were tested for binding to HLA-B*35, one of the common B-types in West Africa. Three 9-mer peptides bound with high affinity to HLA-B*3501 and displayed low dissociation rates of peptide-major histocompatibility complexes (MHCs). IC(50) and half-life values of peptide-MHC class I complexes were...

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Publication status:
Published

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Publisher copy:
10.1086/319267

Authors


Hammond, AS More by this author
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Journal:
The Journal of infectious diseases
Volume:
183
Issue:
6
Pages:
928-934
Publication date:
2001-03-05
DOI:
EISSN:
1537-6613
ISSN:
0022-1899
URN:
uuid:f26d9358-4abb-4b01-b7ef-50cfc90ef998
Source identifiers:
4194
Local pid:
pubs:4194

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