Pseudomonas pseudomallei resistance to beta-lactam antibiotics due to alterations in the chromosomally encoded beta-lactamase.

Godfrey, A; Wong, S; Dance, D; Chaowagul, W; Bryan, L

Journal article

Pseudomonas pseudomallei resistance to beta-lactam antibiotics due to alterations in the chromosomally encoded beta-lactamase.

Abstract:: Pseudomonas pseudomallei, the causative agent of melioidosis, is generally susceptible to some of the newer extended-spectrum cephalosporins or to combinations of a beta-lactam and clavulanic acid, a beta-lactamase inhibitor. Resistance to these agents may, however, emerge during treatment. We report on alterations in the chromosomal beta-lactamase associated with the development of resistance. Three resistance patterns resulted from three different mechanisms in the strains investigated. Derepression of the chromosomal enzyme resulted in a general increase in the MICs of all of the beta-lactams tested. The second mechanism observed was an insensitivity to inhibition of the beta-lactamase by clavulanic acid. In this case, the level of susceptibility to beta-lactams as independent entities remained unchanged. The final "resistance" pattern occurred in a patient treated with ceftazidime and resulted in a beta-lactamase that was capable of hydrolyzing this antibiotic at detectable levels, but with reduced efficacy against other beta-lactams. The net result was a strain that was generally susceptible to all of the beta-lactams tested except ceftazidime. In all cases, the level of susceptibility to antibiotics other than beta-lactams remained unchanged. Such variability found within one genus over a relatively short time course suggests that treatment of infections caused by this organism should be carefully monitored to detect susceptibility alterations to the chosen therapy.

Publication status:: Published

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APA Style

Godfrey, A., Wong, S., Dance, D., Chaowagul, W., & Bryan, L. (1991). Pseudomonas pseudomallei resistance to beta-lactam antibiotics due to alterations in the chromosomally encoded beta-lactamase. Antimicrobial Agents and Chemotherapy, 35(8), 1635–1640.

MLA Style

Godfrey, A., et al. “Pseudomonas Pseudomallei Resistance to Beta-Lactam Antibiotics Due to Alterations in the Chromosomally Encoded Beta-Lactamase.” Antimicrobial Agents and Chemotherapy, vol. 35, no. 8, 1991, pp. 1635–40.

Chicago Style

Godfrey, A, S Wong, D Dance, W Chaowagul, and L Bryan. 1991. “Pseudomonas Pseudomallei Resistance to Beta-Lactam Antibiotics Due to Alterations in the Chromosomally Encoded Beta-Lactamase.” Antimicrobial Agents and Chemotherapy 35 (8): 1635–40.
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