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Influence of correlated antigen presentation on T-cell negative selection in the thymus

Abstract:

The thymus is the primary organ for the generation of naive T cells, a key component of the immune system. Tolerance of T cells to self is achieved primarily in the thymic medulla, where immature T cells (thymocytes) sample self-peptides presented by medullary thymic epithelial cells (mTECs). A sufficiently strong interaction activates the thymocytes leading to negative selection. A key question of current interest is whether there is any structure in the manner in which mTECs present peptide...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1098/rsif.2018.0311

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More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Mathematical Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Mathematical Institute
Oxford college:
Mansfield College
Role:
Author
ORCID:
0000-0003-3347-6024
Publisher:
Royal Society Publisher's website
Journal:
Journal of the Royal Society Interface Journal website
Volume:
15
Issue:
148
Pages:
Article: 20180311
Publication date:
2018-11-07
Acceptance date:
2018-09-26
DOI:
EISSN:
1742-5662
ISSN:
1742-5689
Pubs id:
pubs:923767
URN:
uri:f25cb724-ad2b-47f7-a5dd-8d03bc0478b5
UUID:
uuid:f25cb724-ad2b-47f7-a5dd-8d03bc0478b5
Local pid:
pubs:923767

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