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Journal article

FLT3 receptor and ligand are dispensable for maintenance and posttransplantation expansion of mouse hematopoietic stem cells.

Abstract:

Originally cloned from hematopoietic stem cell (HSC) populations and its ligand being extensively used to promote ex vivo HSC expansion, the FMS-like tyrosine kinase 3 (FLT3; also called FLK2) receptor and its ligand (FL) were expected to emerge as an important physiologic regulator of HSC maintenance and expansion. However, the role of FLT3 receptor and ligand in HSC regulation remains unclear and disputed. Herein, using Fl-deficient mice, we establish for the first time that HSC expansion i...

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Publication status:
Published

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Journal:
Blood More from this journal
Volume:
113
Issue:
15
Pages:
3453-3460
Publication date:
2009-04-01
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
Language:
English
Keywords:
Pubs id:
pubs:246575
UUID:
uuid:f25259f3-91a4-43ed-8758-e6dd3c28cca0
Local pid:
pubs:246575
Source identifiers:
246575
Deposit date:
2012-12-19

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