- Abstract:
-
We recently introduced a novel scheme combining electron-transfer and higher-energy collision dissociation (termed EThcD), for improved peptide ion fragmentation and identification. We reasoned that phosphosite localization, one of the major hurdles in high-throughput phosphoproteomics, could also highly benefit from the generation of such EThcD spectra. Here, we systematically assessed the impact on phosphosite localization utilizing EThcD in comparison to methods employing either ETD or HCD...
Expand abstract - Publication status:
- Published
- Journal:
- Journal of proteome research
- Volume:
- 12
- Issue:
- 3
- Pages:
- 1520-1525
- Publication date:
- 2013-03-05
- DOI:
- EISSN:
-
1535-3907
- ISSN:
-
1535-3893
- URN:
-
uuid:f24e9dc4-5e97-411f-b802-511219e62db9
- Source identifiers:
-
384543
- Local pid:
- pubs:384543
- Language:
- English
- Keywords:
- Copyright date:
- 2013
Journal article
Unambiguous phosphosite localization using electron-transfer/higher-energy collision dissociation (EThcD).
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