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Journal article

Pharmacokinetic interactions between primaquine and chloroquine.

Abstract:

Chloroquine combined with primaquine has been the standard radical curative regimen for Plasmodium vivax and Plasmodium ovale malaria for over half a century. In an open-label crossover pharmacokinetic study, 16 healthy volunteers (4 males and 12 females) aged 20 to 47 years were randomized into two groups of three sequential hospital admissions to receive a single oral dose of 30 mg (base) primaquine, 600 mg (base) chloroquine, and the two drugs together. The coadministration of the two drug...

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Publication status:
Published

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Publisher copy:
10.1128/AAC.02794-13

Authors


Pukrittayakamee, S More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Tropical Medicine
Jittamala, P More by this author
Charunwatthana, P More by this author
Lawpoolsri, S More by this author
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Journal:
Antimicrobial agents and chemotherapy
Volume:
58
Issue:
6
Pages:
3354-3359
Publication date:
2014-06-05
DOI:
EISSN:
1098-6596
ISSN:
0066-4804
URN:
uuid:f24c696a-be39-4b58-94d5-98426d1b06cb
Source identifiers:
458781
Local pid:
pubs:458781
Language:
English

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