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Ultrasound-induced cavitation enhances the delivery and therapeutic efficacy of an oncolytic virus in an in vitro model.

Abstract:

We investigated whether ultrasound-induced cavitation at 0.5 MHz could improve the extravasation and distribution of a potent breast cancer-selective oncolytic adenovirus, AdEHE2F-Luc, to tumour regions that are remote from blood vessels. We developed a novel tumour-mimicking model consisting of a gel matrix containing human breast cancer cells traversed by a fluid channel simulating a tumour blood vessel, through which the virus and microbubbles could be made to flow. Ultrasonic pressures we...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MPLS, Engineering Science
Role:
Author
Journal:
Journal of controlled release : official journal of the Controlled Release Society
Volume:
157
Issue:
2
Pages:
235-242
Publication date:
2012-01-05
DOI:
EISSN:
1873-4995
ISSN:
0168-3659
URN:
uuid:f23f5e4b-8572-4764-88d8-1d0b121b4208
Source identifiers:
186658
Local pid:
pubs:186658

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